AFC East
Buffalo Bills
12-52025 Season
Points For
481
Points Against
365
Differential
+116
2025 Schedule
| Wk | Date | Opponent | Result | Score | Venue |
|---|---|---|---|---|---|
| 1 | Sep 7, 2025 |  Baltimore Ravens | W | 41-40 | New Era Field |
| 2 | Sep 14, 2025 | @ New York Jets | W | 30-10 | MetLife Stadium |
| 3 | Sep 18, 2025 |  Miami Dolphins | W | 31-21 | New Era Field |
| 4 | Sep 28, 2025 |  New Orleans Saints | W | 31-19 | New Era Field |
| 5 | Oct 5, 2025 |  New England Patriots | L | 20-23 | New Era Field |
| 6 | Oct 13, 2025 | @ Atlanta Falcons | L | 14-24 | Mercedes-Benz Stadium |
| 8 | Oct 26, 2025 | @ Carolina Panthers | W | 40-9 | Bank of America Stadium |
| 9 | Nov 2, 2025 |  Kansas City Chiefs | W | 28-21 | New Era Field |
| 10 | Nov 9, 2025 | @Miami Dolphins | L | 13-30 | Hard Rock Stadium |
| 11 | Nov 16, 2025 |  Tampa Bay Buccaneers | W | 44-32 | New Era Field |
| 12 | Nov 20, 2025 | @ Houston Texans | L | 19-23 | NRG Stadium |
| 13 | Nov 30, 2025 | @ Pittsburgh Steelers | W | 26-7 | Acrisure Stadium |
| 14 | Dec 7, 2025 |  Cincinnati Bengals | W | 39-34 | New Era Field |
| 15 | Dec 14, 2025 | @New England Patriots | W | 35-31 | Gillette Stadium |
| 16 | Dec 21, 2025 | @ Cleveland Browns | W | 23-20 | FirstEnergy Stadium |
| 17 | Dec 28, 2025 |  Philadelphia Eagles | L | 12-13 | New Era Field |
| 18 | Jan 4, 2026 | New York Jets | W | 35-8 | New Era Field |
| 19WC | Jan 11, 2026 | @ Jacksonville Jaguars | W | 27-24 | TIAA Bank Stadium |
| 20DIV | Jan 17, 2026 | @ Denver Broncos | L | 30-33 | Empower Field at Mile High |