AFC East
Buffalo Bills
11-62021 Season
Points For
483
Points Against
289
Differential
+194
2021 Schedule
| Wk | Date | Opponent | Result | Score | Venue |
|---|---|---|---|---|---|
| 1 | Sep 12, 2021 |  Pittsburgh Steelers | L | 16-23 | New Era Field |
| 2 | Sep 19, 2021 | @ Miami Dolphins | W | 35-0 | Hard Rock Stadium |
| 3 | Sep 26, 2021 |  Washington Commanders | W | 43-21 | New Era Field |
| 4 | Oct 3, 2021 |  Houston Texans | W | 40-0 | New Era Field |
| 5 | Oct 10, 2021 | @ Kansas City Chiefs | W | 38-20 | GEHA Field at Arrowhead Stadium |
| 6 | Oct 18, 2021 | @ Tennessee Titans | L | 31-34 | Nissan Stadium |
| 8 | Oct 31, 2021 | Miami Dolphins | W | 26-11 | New Era Field |
| 9 | Nov 7, 2021 | @ Jacksonville Jaguars | L | 6-9 | TIAA Bank Stadium |
| 10 | Nov 14, 2021 | @ New York Jets | W | 45-17 | MetLife Stadium |
| 11 | Nov 21, 2021 |  Indianapolis Colts | L | 15-41 | New Era Field |
| 12 | Nov 25, 2021 | @ New Orleans Saints | W | 31-6 | Mercedes-Benz Superdome |
| 13 | Dec 6, 2021 |  New England Patriots | L | 10-14 | New Era Field |
| 14 | Dec 12, 2021 | @ Tampa Bay Buccaneers | L | 27-33 | Raymond James Stadium |
| 15 | Dec 19, 2021 |  Carolina Panthers | W | 31-14 | New Era Field |
| 16 | Dec 26, 2021 | @New England Patriots | W | 33-21 | Gillette Stadium |
| 17 | Jan 2, 2022 |  Atlanta Falcons | W | 29-15 | New Era Field |
| 18 | Jan 9, 2022 | New York Jets | W | 27-10 | New Era Field |
| 19WC | Jan 15, 2022 | New England Patriots | W | 47-17 | New Era Field |
| 20DIV | Jan 23, 2022 | @Kansas City Chiefs | L | 36-42 | GEHA Field at Arrowhead Stadium |