NFC West
San Francisco 49ers
12-52025 Season
Points For
437
Points Against
371
Differential
+66
2025 Schedule
| Wk | Date | Opponent | Result | Score | Venue |
|---|---|---|---|---|---|
| 1 | Sep 7, 2025 | @ Seattle Seahawks | W | 17-13 | Lumen Field |
| 2 | Sep 14, 2025 | @ New Orleans Saints | W | 26-21 | Mercedes-Benz Superdome |
| 3 | Sep 21, 2025 |  Arizona Cardinals | W | 16-15 | Levi's Stadium |
| 4 | Sep 28, 2025 |  Jacksonville Jaguars | L | 21-26 | Levi's Stadium |
| 5 | Oct 2, 2025 | @ Los Angeles Rams | W | 26-23 | SoFi Stadium |
| 6 | Oct 12, 2025 | @ Tampa Bay Buccaneers | L | 19-30 | Raymond James Stadium |
| 7 | Oct 19, 2025 |  Atlanta Falcons | W | 20-10 | Levi's Stadium |
| 8 | Oct 26, 2025 | @ Houston Texans | L | 15-26 | NRG Stadium |
| 9 | Nov 2, 2025 | @ New York Giants | W | 34-24 | MetLife Stadium |
| 10 | Nov 9, 2025 | Los Angeles Rams | L | 26-42 | Levi's Stadium |
| 11 | Nov 16, 2025 | @Arizona Cardinals | W | 41-22 | State Farm Stadium |
| 12 | Nov 24, 2025 |  Carolina Panthers | W | 20-9 | Levi's Stadium |
| 13 | Nov 30, 2025 | @ Cleveland Browns | W | 26-8 | FirstEnergy Stadium |
| 15 | Dec 14, 2025 |  Tennessee Titans | W | 37-24 | Levi's Stadium |
| 16 | Dec 22, 2025 | @ Indianapolis Colts | W | 48-27 | Lucas Oil Stadium |
| 17 | Dec 28, 2025 |  Chicago Bears | W | 42-38 | Levi's Stadium |
| 18 | Jan 3, 2026 | Seattle Seahawks | L | 3-13 | Levi's Stadium |
| 19WC | Jan 11, 2026 | @ Philadelphia Eagles | W | 23-19 | Lincoln Financial Field |
| 20DIV | Jan 17, 2026 | @Seattle Seahawks | L | 6-41 | Lumen Field |