NFC West
San Francisco 49ers
10-72021 Season
Points For
427
Points Against
365
Differential
+62
2021 Schedule
| Wk | Date | Opponent | Result | Score | Venue |
|---|---|---|---|---|---|
| 1 | Sep 12, 2021 | @ Detroit Lions | W | 41-33 | Ford Field |
| 2 | Sep 19, 2021 | @ Philadelphia Eagles | W | 17-11 | Lincoln Financial Field |
| 3 | Sep 26, 2021 |  Green Bay Packers | L | 28-30 | Levi's Stadium |
| 4 | Oct 3, 2021 |  Seattle Seahawks | L | 21-28 | Levi's Stadium |
| 5 | Oct 10, 2021 | @ Arizona Cardinals | L | 10-17 | State Farm Stadium |
| 7 | Oct 24, 2021 |  Indianapolis Colts | L | 18-30 | Levi's Stadium |
| 8 | Oct 31, 2021 | @ Chicago Bears | W | 33-22 | Soldier Field |
| 9 | Nov 7, 2021 | Arizona Cardinals | L | 17-31 | Levi's Stadium |
| 10 | Nov 15, 2021 |  Los Angeles Rams | W | 31-10 | Levi's Stadium |
| 11 | Nov 21, 2021 | @ Jacksonville Jaguars | W | 30-10 | TIAA Bank Stadium |
| 12 | Nov 28, 2021 |  Minnesota Vikings | W | 34-26 | Levi's Stadium |
| 13 | Dec 5, 2021 | @Seattle Seahawks | L | 23-30 | Lumen Field |
| 14 | Dec 12, 2021 | @ Cincinnati Bengals | W | 26-23 | Paul Brown Stadium |
| 15 | Dec 19, 2021 |  Atlanta Falcons | W | 31-13 | Levi's Stadium |
| 16 | Dec 23, 2021 | @ Tennessee Titans | L | 17-20 | Nissan Stadium |
| 17 | Jan 2, 2022 |  Houston Texans | W | 23-7 | Levi's Stadium |
| 18 | Jan 9, 2022 | @Los Angeles Rams | W | 27-24 | SoFi Stadium |
| 19WC | Jan 16, 2022 | @ Dallas Cowboys | W | 23-17 | AT&T Stadium |
| 20DIV | Jan 22, 2022 | @Green Bay Packers | W | 13-10 | Lambeau Field |
| 21CON | Jan 30, 2022 | @Los Angeles Rams | L | 17-20 | SoFi Stadium |