NFC West
San Francisco 49ers
2-142016 Season
Points For
309
Points Against
480
Differential
-171
2016 Schedule
| Wk | Date | Opponent | Result | Score | Venue |
|---|---|---|---|---|---|
| 1 | Sep 12, 2016 |  Los Angeles Rams | W | 28-0 | Levi's Stadium |
| 2 | Sep 18, 2016 | @ Carolina Panthers | L | 27-46 | Bank of America Stadium |
| 3 | Sep 25, 2016 | @ Seattle Seahawks | L | 18-37 | CenturyLink Field |
| 4 | Oct 2, 2016 |  Dallas Cowboys | L | 17-24 | Levi's Stadium |
| 5 | Oct 6, 2016 |  Arizona Cardinals | L | 21-33 | Levi's Stadium |
| 6 | Oct 16, 2016 | @ Buffalo Bills | L | 16-45 | New Era Field |
| 7 | Oct 23, 2016 |  Tampa Bay Buccaneers | L | 17-34 | Levi's Stadium |
| 9 | Nov 6, 2016 |  New Orleans Saints | L | 23-41 | Levi's Stadium |
| 10 | Nov 13, 2016 | @Arizona Cardinals | L | 20-23 | University of Phoenix Stadium |
| 11 | Nov 20, 2016 |  New England Patriots | L | 17-30 | Levi's Stadium |
| 12 | Nov 27, 2016 | @ Miami Dolphins | L | 24-31 | Hard Rock Stadium |
| 13 | Dec 4, 2016 | @ Chicago Bears | L | 6-26 | Soldier Field |
| 14 | Dec 11, 2016 |  New York Jets | L | 17-23 | Levi's Stadium |
| 15 | Dec 18, 2016 | @ Atlanta Falcons | L | 13-41 | Georgia Dome |
| 16 | Dec 24, 2016 | @Los Angeles Rams | W | 22-21 | Los Angeles Memorial Coliseum |
| 17 | Jan 1, 2017 | Seattle Seahawks | L | 23-25 | Levi's Stadium |