AFC South
Indianapolis Colts
8-92025 Season
Points For
466
Points Against
412
Differential
+54
2025 Schedule
| Wk | Date | Opponent | Result | Score | Venue |
|---|---|---|---|---|---|
| 1 | Sep 7, 2025 |  Miami Dolphins | W | 33-8 | Lucas Oil Stadium |
| 2 | Sep 14, 2025 |  Denver Broncos | W | 29-28 | Lucas Oil Stadium |
| 3 | Sep 21, 2025 | @ Tennessee Titans | W | 41-20 | Nissan Stadium |
| 4 | Sep 28, 2025 | @ Los Angeles Rams | L | 20-27 | SoFi Stadium |
| 5 | Oct 5, 2025 |  Las Vegas Raiders | W | 40-6 | Lucas Oil Stadium |
| 6 | Oct 12, 2025 |  Arizona Cardinals | W | 31-27 | Lucas Oil Stadium |
| 7 | Oct 19, 2025 | @ Los Angeles Chargers | W | 38-24 | SoFi Stadium |
| 8 | Oct 26, 2025 | Tennessee Titans | W | 38-14 | Lucas Oil Stadium |
| 9 | Nov 2, 2025 | @ Pittsburgh Steelers | L | 20-27 | Acrisure Stadium |
| 10 | Nov 9, 2025 |  Atlanta Falcons | W | 31-25 | Lucas Oil Stadium |
| 12 | Nov 23, 2025 | @ Kansas City Chiefs | L | 20-23 | GEHA Field at Arrowhead Stadium |
| 13 | Nov 30, 2025 |  Houston Texans | L | 16-20 | Lucas Oil Stadium |
| 14 | Dec 7, 2025 | @ Jacksonville Jaguars | L | 19-36 | TIAA Bank Stadium |
| 15 | Dec 14, 2025 | @ Seattle Seahawks | L | 16-18 | Lumen Field |
| 16 | Dec 22, 2025 |  San Francisco 49ers | L | 27-48 | Lucas Oil Stadium |
| 17 | Dec 28, 2025 | Jacksonville Jaguars | L | 17-23 | Lucas Oil Stadium |
| 18 | Jan 4, 2026 | @Houston Texans | L | 30-38 | NRG Stadium |