AFC South
Indianapolis Colts
9-82021 Season
Points For
451
Points Against
365
Differential
+86
2021 Schedule
| Wk | Date | Opponent | Result | Score | Venue |
|---|---|---|---|---|---|
| 1 | Sep 12, 2021 |  Seattle Seahawks | L | 16-28 | Lucas Oil Stadium |
| 2 | Sep 19, 2021 |  Los Angeles Rams | L | 24-27 | Lucas Oil Stadium |
| 3 | Sep 26, 2021 | @ Tennessee Titans | L | 16-25 | Nissan Stadium |
| 4 | Oct 3, 2021 | @ Miami Dolphins | W | 27-17 | Hard Rock Stadium |
| 5 | Oct 11, 2021 | @ Baltimore Ravens | L | 25-31 | M&T Bank Stadium |
| 6 | Oct 17, 2021 |  Houston Texans | W | 31-3 | Lucas Oil Stadium |
| 7 | Oct 24, 2021 | @ San Francisco 49ers | W | 30-18 | Levi's Stadium |
| 8 | Oct 31, 2021 | Tennessee Titans | L | 31-34 | Lucas Oil Stadium |
| 9 | Nov 4, 2021 |  New York Jets | W | 45-30 | Lucas Oil Stadium |
| 10 | Nov 14, 2021 |  Jacksonville Jaguars | W | 23-17 | Lucas Oil Stadium |
| 11 | Nov 21, 2021 | @ Buffalo Bills | W | 41-15 | New Era Field |
| 12 | Nov 28, 2021 |  Tampa Bay Buccaneers | L | 31-38 | Lucas Oil Stadium |
| 13 | Dec 5, 2021 | @Houston Texans | W | 31-0 | NRG Stadium |
| 15 | Dec 18, 2021 |  New England Patriots | W | 27-17 | Lucas Oil Stadium |
| 16 | Dec 25, 2021 | @ Arizona Cardinals | W | 22-16 | State Farm Stadium |
| 17 | Jan 2, 2022 |  Las Vegas Raiders | L | 20-23 | Lucas Oil Stadium |
| 18 | Jan 9, 2022 | @Jacksonville Jaguars | L | 11-26 | TIAA Bank Stadium |