AFC East
Buffalo Bills
7-92016 Season
Points For
399
Points Against
378
Differential
+21
2016 Schedule
| Wk | Date | Opponent | Result | Score | Venue |
|---|---|---|---|---|---|
| 1 | Sep 11, 2016 | @ Baltimore Ravens | L | 7-13 | M&T Bank Stadium |
| 2 | Sep 15, 2016 |  New York Jets | L | 31-37 | New Era Field |
| 3 | Sep 25, 2016 |  Arizona Cardinals | W | 33-18 | New Era Field |
| 4 | Oct 2, 2016 | @ New England Patriots | W | 16-0 | Gillette Stadium |
| 5 | Oct 9, 2016 | @ Los Angeles Rams | W | 30-19 | Los Angeles Memorial Coliseum |
| 6 | Oct 16, 2016 |  San Francisco 49ers | W | 45-16 | New Era Field |
| 7 | Oct 23, 2016 | @ Miami Dolphins | L | 25-28 | Hard Rock Stadium |
| 8 | Oct 30, 2016 | New England Patriots | L | 25-41 | New Era Field |
| 9 | Nov 7, 2016 | @ Seattle Seahawks | L | 25-31 | CenturyLink Field |
| 11 | Nov 20, 2016 | @ Cincinnati Bengals | W | 16-12 | Paul Brown Stadium |
| 12 | Nov 27, 2016 |  Jacksonville Jaguars | W | 28-21 | New Era Field |
| 13 | Dec 4, 2016 | @ OAK | L | 24-38 | Oakland-Alameda County Coliseum |
| 14 | Dec 11, 2016 |  Pittsburgh Steelers | L | 20-27 | New Era Field |
| 15 | Dec 18, 2016 |  Cleveland Browns | W | 33-13 | New Era Field |
| 16 | Dec 24, 2016 | Miami Dolphins | L | 31-34 | New Era Field |
| 17 | Jan 1, 2017 | @New York Jets | L | 10-30 | MetLife Stadium |